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Effects of different bronchoalveolar lavage methods on tracheobronchial foreign body patients
Author(s) -
Luo HuaNan,
Ma SiJing,
Guo HaiLi,
Wang ZhengHui,
Ren XiaoYong
Publication year - 2016
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.25484
Subject(s) - medicine , bronchoalveolar lavage , lidocaine , dexamethasone , epinephrine , anesthesia , saline , bronchospasm , group b , group a , hypoxemia , gastroenterology , surgery , asthma , lung
Objectives/Hypothesis To compare the different effects of bronchoalveolar lavage (BAL) with diverse combinations of lidocaine, epinephrine, and dexamethasone on pediatric patients with an inhaled tracheobronchial foreign body (TFB). Study Design Randomized controlled study. Methods Two hundred forty cases of pediatric patients with inhaled TFB were included in this study, and were randomly divided into four groups using three kinds of drugs for BAL, namely 0.9% saline (S) group, 2% lidocaine with diluted epinephrine (LE) group, 2% lidocaine with diluted epinephrine and 0.5% dexamethasone (LED), control group (C) without BAL. The incidences of intraoperative or postoperative complications and recovery periods were compared. Meanwhile, the concentrations of interleukin (IL)−1β, IL‐6, and tumor necrosis factor (TNF)‐α in BAL fluids and plasma were evaluated by enzyme‐linked immunosorbent assay. Results The incidences of bronchospasm, hypoxemia, and postoperative fever were significantly lower in the LED group than other groups ( P < .001). Fever after the TFB removal procedure appeared later in the LED group than the other groups. The improvement and healing periods in the LE and LED groups were significantly shorter than those in the C and S groups ( P < .001). The concentrations of IL‐1β, IL‐6, and TNF ‐ α in BAL fluids were significantly higher in the LE and LED groups than those in the S group ( P < .001), but those in the plasma of the C and S groups were lower compared with the LE and LED groups ( P < .001). Conclusions BAL with lidocaine, epinephrine, and dexamethasone could promote recovery for TFB patients and reduce incidences of complications, possibly by regulating release of proinflammatory cytokines. Level of Evidence 1b. Laryngoscope , 126:1000–1005, 2016