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Sinonasal malignancies: A population‐based analysis of site‐specific incidence and survival
Author(s) -
Dutta Rahul,
Dubal Pariket M.,
Svider Peter F.,
Liu James K.,
Baredes Soly,
Eloy Jean Anderson
Publication year - 2015
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.25465
Subject(s) - medicine , incidence (geometry) , nasal cavity , cancer registry , malignancy , population , epidemiology , cancer , surveillance, epidemiology, and end results , surgery , physics , environmental health , optics
Objectives/Hypothesis Sinonasal malignancies vary in behavior according to histology and anatomical location. Incidence, survival, and optimal treatment for these lesions are thus uncertain in various cases. Our objective was to utilize a national population‐based registry to identify the most common sinonasal histopathologies by anatomical site, and subsequently analyze the data by incidence trends, survival rates, patient demographics, and treatment modalities. Study Design Retrospective analysis of the United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry. Methods The SEER database was examined for patients diagnosed with sinonasal malignancies between 1973 and 2011. Data were stratified according to anatomical site, incidence, survival, histology, staging, and patient demographics. Therapy‐based outcomes were analyzed for cases from 1983 to 2011. Results A total of 13,295 patients were identified, with an incidence of 0.83 per 100,000 people. Males comprised 58.6% of cases. Whites represented 81.5% of cases, while blacks comprised 8.7%. Squamous cell carcinoma was the most common histology (41.9%) across all sites of the sinonasal tract. The most common anatomical site of malignancy was the nasal cavity (45.7%), and least common was the frontal sinus (1.2%). For single sites, 5‐year disease‐specific survival (DSS) was highest for nasal cavity tumors (67.1%) and lowest for overlapping sinus malignancies (37.6%). The overall 5‐year DSS for all sinonasal malignancies was 53.7%. Conclusion Sinonasal malignancies are rare entities with poor overall prognosis. By anatomical site, prognosis is best for nasal cavity cancers and worst for overlapping lesions. Level of Evidence 4. Laryngoscope , 125:2491–2497, 2015