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Post‐sinus surgery insertion of steroid‐eluting bioabsorbable intranasal devices: A systematic review
Author(s) -
Rizan Chantelle,
Elhassan Hassan A.
Publication year - 2016
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.25460
Subject(s) - medicine , perioperative , randomized controlled trial , adverse effect , surgery , mometasone furoate , nasal administration , systematic review , functional endoscopic sinus surgery , medline , regimen , clinical trial , corticosteroid , sinusitis , political science , law , immunology
Objectives/Hypothesis Postendoscopic sinus surgery corticosteroid administration reduces polyp formation, inflammation, and adhesions. Steroid‐eluting bioabsorbable intranasal devices (SEBID) are novel interventions thought to improve local drug delivery while minimizing systemic side effects. The primary aim of this systematic review is to evaluate the efficacy and safety of bioabsorbable SEBIDs. The secondary aim is to inform clinical recommendations and to introduce clinicians to this novel technology. Study Design MEDLINE, PubMed, Embase, and Cochrane Database were searched according to Preferred Reporting Items for Systematic Review and Meta‐Analyses guidelines. Methods Original articles assessing the efficacy of SEBIDs inserted after endoscopic sinus surgery. For each study, we recorded the efficacy endpoints and safety outcomes. Results Seven studies met the inclusion criteria from 737 initial articles identified, including five prospective randomized controlled trials and two prospective single‐cohort studies involving 394 sinuses within treatment arms. Patients were followed up for 2 to 6 months. Six studies demonstrated SEBID efficacy with statistical significance ( P < 0.05). Steroid‐eluting bioabsorbable intranasal devices were effective in reducing adhesion formation, polyp formation, inflammation, Lund‐Kennedy scores, and perioperative sinus endoscopy scores. The devices improved patient‐reported outcomes and olfaction while reducing postoperative interventions. They were not associated with adverse events and pose no ocular safety risk. Complications in three SEBID applications were reported. Conclusion There is limited data available on SEBIDS; further studies are required to determine whether they are safe and effective adjuncts postendoscopic sinus surgery. Future studies are needed to optimize the dosing regimen, compare devices, and provide long‐term outcomes. Steroid‐eluting bioabsorbable intranasal devices may tentatively be incorporated into future evidence‐based practice. Laryngoscope , 126:86–92, 2016