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Laryngeal adenoid cystic carcinoma: A population‐based perspective
Author(s) -
Dubal Pariket M.,
Svider Peter F.,
Folbe Adam J.,
Lin HoSheng,
Park Richard C.,
Baredes Soly,
Eloy Jean Anderson
Publication year - 2015
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.25448
Subject(s) - adenoid cystic carcinoma , perspective (graphical) , medicine , population , carcinoma , general surgery , pathology , computer science , artificial intelligence , environmental health
Objectives/Hypothesis Adenoid cystic carcinoma (ACC) occurs infrequently in the larynx. Consequently, no large samples describing its clinical behavior are available in the literature. Our objective was to use a nationally representative population‐based resource to evaluate clinical behavior, patient demographics, and outcomes among patients diagnosed with laryngeal ACC (LACC). Study Design Retrospective database analysis. Methods The National Cancer Institute's Surveillance, Epidemiology, and End Results database was analyzed for patients diagnosed with LACC between 1973 and 2011. Patient demographics, incidence, treatment, and survival between LACC and other laryngeal malignancies were compared. Results Of 69 LACC patients, 63.8% were female, 78.2% Caucasian, and the median age was 54 years. LACC patients were much more likely to have subglottic lesions (44.9%) than individuals with other malignancies (1.6%). The incidence of LACC was 0.005/100,000 individuals. The majority of patients with LACC harbored T4 lesions at initial diagnosis, although 87.9% had N0 disease, and only 6.1% had distant metastasis at diagnosis. Disease‐specific survival (DSS) was greater at 1 year for LACC compared to other laryngeal malignancies, but not at 5 or 10 years. Five‐year DSS was greater for LACC patients who underwent surgery versus those who did not undergo surgery. Conclusions This analysis notes that LACC has a low incidence with no significant change in incidence over the study period. Compared to other laryngeal malignancies, LACC has a female preponderance, is much more common in the subglottis, presents at a younger age, and more often presents with T4 disease. Surgery was noted to confer a survival advantage in LACC. Level of Evidence 4. Laryngoscope , 125:2485–2490, 2015