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Chronic invasive fungal sinusitis associated with intranasal drug use
Author(s) -
Pekala Kelly R.,
Clavenna Matthew J.,
Shockley Ross,
Weiss Vivian L.,
Turner Justin H.
Publication year - 2015
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.25429
Subject(s) - medicine , nasal administration , sinusitis , fungal sinusitis , drug , debridement (dental) , surgery , antifungal , dermatology , immunology , pharmacology
Chronic invasive fungal sinusitis (CIFS) is a rare but potentially aggressive form of invasive fungal disease that occurs in immunocompetent patients. We report a case of CIFS in an otherwise healthy young adult associated with intranasal illicit drug abuse. The patient presented with nonhealing nasal septal and palatal perforations. Biopsy demonstrated invasive Aspergillus flavus requiring surgical debridement and extended intravenous antifungal therapy. Tissue necrosis and ulceration related to intranasal drug use should be recognized as a potential risk factor for invasive fungal sinusitis. Laryngoscope , 125:2656–2659, 2015