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Hearing function after intratympanic application of gadolinium‐based contrast agent: A long‐term evaluation
Author(s) -
Louza Julia,
Krause Eike,
Gürkov Robert
Publication year - 2015
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.25259
Subject(s) - medicine , ototoxicity , audiology , hearing loss , observational study , nose , magnetic resonance imaging , population , audiometry , radiology , surgery , environmental health , chemotherapy , cisplatin
Objectives/Hypothesis The aim of this study was to evaluate the long‐term influence of intratympanic gadolinium‐based contrast agent on hearing function in patients with possible Ménière's disease and normal auditory thresholds who were undergoing locally enhanced magnetic resonance imaging scans. Study Design Prospective observational cohort study in a tertiary referral university hospital ear, nose, and throat department. Methods Between 2009 and 2012, 17 patients with possible or probable Ménière's disease and a four‐tone pure‐tone average baseline of <25 dB were recruited for our study. Before undergoing intratympanic injection of gadolinium‐based contrast agent, all patients underwent a complete audiological evaluation. The study population was then invited back after at least 6 months postinjection for a follow‐up auditory evaluation. This consisted of comprehensive clinical and audiological tests on both sides and were evaluated according to the ototoxicity guidelines. Results A long‐term evaluation of our study group revealed no significant difference in the air‐conduction pure‐tone average. Furthermore, no statistical difference at individual frequencies compared to baseline was found. There was no evidence of ototoxicity in the injected ear. Conclusions Long‐term hearing function assessment after intratympanic application of gadolinium‐based agent showed no evidence of ototoxicity. The use of intratympanic gadolinium‐based agent in the diagnosis of Ménièrés disease is currently a helpful tool, and seems to be a safe method, especially with regard to auditory function. Level of Evidence 4. Laryngoscope , 125:2366–2370, 2015