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The influence of spray cryotherapy on wound healing following endoscopic sinus surgery in chronic rhinosinusitis
Author(s) -
Albu Silviu,
Trombitas Veronica,
Vlad Diana,
Emanuelli Enzo
Publication year - 2016
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.25257
Subject(s) - medicine , cryotherapy , surgery , randomized controlled trial , endoscopy , wound healing , perioperative , chronic rhinosinusitis , edema , endoscopic sinus surgery , saline , anesthesia
Objectives/Hypothesis The aim of this study was to assess the influence of spray cryotherapy on wound healing following endoscopic sinus surgery (ESS). Study Design A prospective, randomized, double‐blinded, controlled trial. Methods The study included 22 consecutive adult patients with chronic rhinosinusitis with and without polyps scheduled for bilateral ESS. At the end of the surgical procedure, patients were randomized to the distribution of spray cryotherapy in one middle meatus and saline contralaterally. Outcomes were only measured for endoscopy scores. Thus, postoperative healing and the amount of edema, crusting, secretions, and scarring were assessed using the validated Lund‐Kennedy and Perioperative Sinus Endoscopy (POSE) scores. Results There were no baseline differences concerning POSE and Lund‐Kennedy scores between the two groups. Nevertheless, a significant difference was recorded at one, 2, 4, 8, and 12 weeks in both POSE ( P = .001, P = .012, P = .02, P = .006, P = .001) and Lund‐Kennedy ( P = .002, P = .005, P = .02, P = .02, P = .03) scores. Conclusions These preliminary results reveal an improvement in postoperative scores, demonstrating enhanced healing following spray cryotherapy. However, without patient subjective outcomes, the study is limited. Additional studies with longer follow‐up and larger samples are needed to describe the effects of cryotherapy on wound healing. Level of Evidence 1b. Laryngoscope , 126:25–32, 2016