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A systematic review of computed tomography detection of cartilage invasion in laryngeal carcinoma
Author(s) -
Adolphs Anda P. J.,
Boersma Nienke A.,
Diemel Babette D. M.,
Eding Joep E. C.,
Flokstra Francien E.,
Wegner Inge,
Grolman Wilko,
Braunius Weibel
Publication year - 2015
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.25145
Subject(s) - medicine , thyroid cartilage , predictive value , cartilage , cochrane library , radiology , carcinoma , thyroid carcinoma , predictive value of tests , positive predicative value , meta analysis , larynx , pathology , surgery , thyroid , anatomy
Objectives/Hypothesis This systematic review aimed to assess the diagnostic value of computed tomography (CT) in detecting cartilage invasion among patients with laryngeal carcinoma. Data Sources PubMed, Embase, and the Cochrane Library. Review Methods A search in the previously mentioned databases was performed to identify relevant articles. Articles comparing cartilage invasion on CT with histology were selected. After critical appraisal, articles of adequate relevance and validity were included in further analysis. Prevalences, sensitivity, specificity, positive predictive values, and negative predictive values were extracted from the included articles. Results Four studies were included in the final analysis. Only one study examined the positive predictive value and negative predictive value for invasion of any laryngeal cartilage, and they were 87% and 56%, respectively. The positive predictive value and negative predictive value for thyroid cartilage invasion were investigated in three studies and ranged from 44% to 80% and from 85% to 100%, respectively. The negative predictive value is likely underestimated due to selection bias, whereas the positive predictive value is likely overestimated. Conclusions CT imaging is a suitable tool to assess laryngeal cartilage invasion, especially regarding the thyroid cartilage. Level of Evidence NA Laryngoscope , 125:1650–1655, 2015