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Prognostic factors in head and neck Ewing sarcoma family of tumors
Author(s) -
Biswas Bivas,
Thakar Alok,
Mohanti Bidhu K.,
Vishnubhatla Sreenivas,
Bakhshi Sameer
Publication year - 2015
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.24985
Subject(s) - medicine , chemotherapy , radiation therapy , head and neck cancer , sarcoma , surgery , multivariate analysis , oncology , ewing's sarcoma , head and neck , pathology
Objectives/Hypothesis Data on the Ewing sarcoma family of tumors (ESFT) of the head and neck region with uniform chemotherapy protocols are minimal. We evaluated outcome and prognostic factors in these patients treated with a uniform chemotherapy protocol. Study Design Single institution observational study. Methods This is a single‐institution review of patients treated between June 2003 and November 2011. Patients received neoadjuvant chemotherapy (NACT), surgery, and/or radiotherapy as a local treatment followed by adjuvant chemotherapy. Results Thirty‐five cases of head and neck ESFT were treated with a uniform chemotherapy protocol. The median age was 12 years (range, 1–43 years); three (9%) had metastases. Nine patients underwent surgery, of which eight received adjuvant radiotherapy; 23 received definitive radiotherapy post‐NACT. At a median follow‐up of 58 months (range. 3.7–133.7 months), 5‐year event‐free survival (EFS), overall survival (OS), and local control rate were 55.1 ± 9.2%, 68.3 ± 8.3%, and 74.1 ± 8.5%, respectively. Multivariate analysis showed that baseline white blood cell (WBC) count independently prognosticated EFS ( P = .04), with patients who had WBC ≤11,000/µL had superior EFS, although no difference for OS was observed. Conclusions This is one of the largest studies of head and neck ESFT treated with a uniform chemotherapy protocol with intent‐to‐treat analysis. Within the limitations of the small size, baseline low WBC count appeared to have a superior outcome. Level of Evidence 2b Laryngoscope , 125:E112–E117, 2015