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Aggressive primary olfactory neuroblastoma of the sphenoclival region: A case report and literature review
Author(s) -
Purohit Bela,
Winder Thomas,
Maggio Ewerton M.,
Kollias Spyros S.
Publication year - 2015
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.24925
Subject(s) - neuroscience , primary (astronomy) , medicine , biology , physics , astronomy
Olfactory neuroblastoma (ONB) is an uncommon malignant tumor of neural crest origin, which commonly arises in the superior nasal cavity. Ectopic origin of an ONB is exceedingly rare. We describe a rare case of an ectopic sphenoclival ONB with extensive involvement of the central skull base and with development of systemic metastases. To our knowledge, ours is the first case that describes the imaging features of this rare entity on computed tomography (CT), magnetic resonance imaging, 18 F‐fluorodeoxyglucose–positron‐emission tomography/CT, and digital subtraction angiography. We also describe the histological features, imaging differentials, and treatment options for this tumor along with a brief literature review. Laryngoscope , 125:822–825, 2015