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The EQ‐5D: A new tool for studying clinical outcomes in chronic rhinosinusitis
Author(s) -
Remenschneider Aaron K.,
D'Amico Laura,
Gray Stacey T.,
Holbrook Eric H.,
Gliklich Richard E.,
Metson Ralph
Publication year - 2015
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.24715
Subject(s) - medicine , chronic rhinosinusitis , eq 5d , visual analogue scale , quality of life (healthcare) , sinusitis , chronic sinusitis , anxiety , depression (economics) , physical therapy , endoscopic sinus surgery , cohort , hospital anxiety and depression scale , refractory (planetary science) , chronic pain , prospective cohort study , surgery , health related quality of life , psychiatry , physics , nursing , disease , astrobiology , economics , macroeconomics
Objectives/Hypothesis To describe the role and applicability of the EuroQol 5‐Dimension, 5‐Level (EQ‐5D‐5L) questionnaire for the assessment of general health‐related quality of life in patients with chronic rhinosinusitis. Study Design Prospective cohort study. Methods The EQ‐5D‐5L was administered to 462 patients with refractory chronic rhinosinusitis before and 3 months after sinus surgery. Preoperative and postoperative scores across each of five health dimensions were analyzed and the results compared to those obtained from two widely used chronic rhinosinusitis outcomes instruments: the Chronic Sinusitis Survey (CSS) and SinoNasal Outcomes Test‐22 (SNOT‐22). Results Three hundred and fifty patients completed the five questions and visual analog scale (VAS) of the EQ‐5D at baseline and at 3 months for a response rate of 75.8%. There were no incomplete questionnaires. The frequency of patients reporting problems in the EQ‐5D domains of pain/discomfort, anxiety/depression, and usual activities decreased following sinus surgery (74.3% vs. 34.4%, 48.6% vs. 31.4%, and 30.6% vs. 19.4%, respectively; all P < 0.001). The domains of mobility and self‐care did not demonstrate statistically significant change. EQ‐5D VAS (standard deviation) improved from 73.4 (16.9) before surgery to 82.0 (14.4) after surgery ( P < 0.001). Preoperative VAS correlated with SNOT‐22 scores (Pearson coefficient of 0.50; P < 0.01). Postoperative change in VAS and SNOT‐22 scores demonstrated moderate correlation (Pearson coefficient of 0.36, P < 0.01). Conclusion The EQ‐5D is a general health measure with sensitivity to clinical change in rhinosinusitis that support its use for monitoring patient outcomes. The limited response burden and ability to directly calculate health utility make it an attractive tool for rhinosinusitis outcomes research. Level of Evidence 2c. Laryngoscope , 125:7–15, 2015