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Glottal gap as an early predictor for permanent laryngoplasty in unilateral vocal fold paralysis
Author(s) -
Fang TuanJen,
Pei YuCheng,
Li HsuehYu,
Wong Alice, M. K.,
Chiang HuiChen
Publication year - 2014
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.24689
Subject(s) - medicine , logistic regression , vocal fold paralysis , cohort , laryngoplasty , cutoff , prospective cohort study , multivariate analysis , surgery , paralysis , larynx , physics , quantum mechanics
Objectives/Hypothesis To assess the possible predictive factors for permanent laryngoplasty (PL) in patients with acute unilateral vocal fold paralysis (UVFP), and to assess the effects of early vocal cord hyaluronic acid injection. Study Design Prospective cohort study. Methods Patients diagnosed with UVFP within the previous 6 months were enrolled. Initial and follow‐up videolaryngostroboscopy, voice laboratory analysis, laryngeal electromyography, and Voice Outcome Survey were performed. Results Fifty newly diagnosed UVFP patients were recruited. Eight were excluded after 12 months of follow‐up and data for 42 patients were analyzed. In patients treated conservatively, the glottal gap was measured on presentation. Normalized glottal gap area (NGGA) was the only predictor of PL ( P = 0.036) according to multivariate logistic regression analysis. A cutoff value of 7.36 resulted in sensitivity of 85.7% and specificity of 80.0% for predicting future PL. The PL rate was significantly higher in patients with an initial NGGA > 7.36 compared with ≤ 7.36. (6/9 vs. 1/13; χ 2 = 6.71; P = 0.010). Among patients with an initial NGGA > 7.36, those who accepted early hyaluronic acid injection had a significantly lower rate of PL (1/11 vs. 6/9; χ 2 = 7.21; P = 0.007) and better social and emotional role functioning at follow‐up. Conclusions The glottal gap on presentation is a robust early predictor of PL. Early, office‐based hyaluronic acid intracordal injection can reduce the need for PL in patients with a large NGGA. Level of Evidence 4. Laryngoscope , 124:2125–2130, 2014