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Predictive accuracy of first post‐treatment PET/CT in HPV‐related oropharyngeal squamous cell carcinoma
Author(s) -
Koshkareva Yekaterina,
Branstetter Barton F.,
Gaughan John P.,
Ferris Robert L.
Publication year - 2014
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.24617
Subject(s) - medicine , positron emission tomography , retrospective cohort study , predictive value , radiology , multivariate analysis , pet ct , basal cell , predictive value of tests , human papillomavirus , nuclear medicine
Objectives/Hypothesis To determine whether the result of first posttreatment positron emission tomography and computed tomography (PET/CT) is predictive of outcome in patients with oropharyngeal squamous cell carcinoma (OPSCC), and whether PET/CT accuracy is affected by human papillomavirus (HPV) status. Study Design Retrospective review. Methods Demographic, clinical, and radiographic data were available for 61 patients with OPSCC, treated in 2004 to 2012 at a single tertiary academic referral center, with at least one baseline and one posttreatment PET/CT. Clinical follow‐up was obtained every 3 months thereafter. The median follow‐up time was 36 months (range 3–100 months). Results Of 61 patients, 48 (79%) had negative first posttreatment PET/CT results; and overall, 18 of the 61 patients (30%) recurred. All accuracy measures for PET/CT were higher in HPV‐positive patients, including a 93% negative predictive value (NPV). Patients with positive PET/CT results had poorer survival on Kaplan‐Meier analyses. On multivariate analysis of factors predictive of recurrence, two parameters were significant: HPV status ( P = 0.0046) and PET/CT result ( P <0.0001). Conclusions A negative first posttreatment PET/CT result is associated with better prognosis and rare recurrence, especially in patients with HPV‐positive status. Less frequent radiologic surveillance is warranted in patients with HPV‐positive OPSCC and a negative first posttreatment PET/CT scan. Level of Evidence 2b. Laryngoscope , 124:1843–1847, 2014