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Voice in female‐to‐male transsexual persons after long‐term androgen therapy
Author(s) -
Cosyns Marjan,
Borsel John,
Wierckx Katrien,
Dedecker David,
Peer Fleur,
Daelman Tine,
Laenen Sofie,
T'Sjoen Guy
Publication year - 2014
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.24480
Subject(s) - medicine , androgen , audiology , luteinizing hormone , testosterone (patch) , hormone therapy , hematocrit , hormone , hormone replacement therapy (female to male) , endocrinology , cancer , breast cancer
Objectives/Hypothesis The aim of the present study was to 1) document voice in a large sample of female‐to‐male transsexual persons (FMT), 2) compare their vocal characteristics with those of heterosexual biological males, and 3) determine hormonal factors with impact on their fundamental frequency. Study Design This was a controlled cross‐sectional study. It is the largest study to date on voice and voice change in FMT, and the first to include a control group and FMT who were under long‐term androgen administration. Methods Thirty‐eight FMT, ranging in age between 22 and 54 years, and 38 controls, frequency matched by age and smoking behavior, underwent a voice assessment that comprised the determination of pitch, intonation, and perturbation parameters measured during sustained vowel production, counting, and reading. Hormonal factors explored were hematocrit, total testosterone level, luteinizing hormone level, and biallelic mean length of the cytosine‐adenine‐guanine (CAG) trinucleotide repeat sequence in the androgen receptor gene. Results It was found that the FMT as a group did not differ significantly from controls for any of the acoustic voice variables studied. However, in about 10% pitch lowering was not totally unproblematic. The lowest‐pitched (i.e., more male) voices were observed in FMT with higher hematocrit and longer CAG repeats. Conclusion After long‐term androgen therapy, FMT generally demonstrate an acceptable male voice. Pitch‐lowering difficulties can be expected in about 10% of cases and appear, at least in part, to be associated with diminished androgen sensitivity. Level of Evidence 3b. Laryngoscope , 124:1409–1414, 2014