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Basaloid squamous cell carcinoma of the oral cavity: An analysis of 92 cases
Author(s) -
Fritsch Valerie A.,
Gerry Daniel R.,
Lentsch Eric J.
Publication year - 2014
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.24384
Subject(s) - medicine , oral cavity , epidermoid carcinoma , basal cell , radiation therapy , pathology , gastroenterology , oncology , dentistry
Objectives/Hypothesis Basaloid squamous cell carcinoma (BSCC) is considered a rare and possibly more aggressive squamous cell carcinoma (SCC) variant. Until now, a series of exclusively oral cavity BSCC patients has not been previously reported. We endeavored to compare BSCC and SCC of the oral cavity, focusing on epidemiologic factors and survival outcomes. Study Design Retrospective analysis of population‐based data. Methods We compared epidemiologic factors, clinicopathologic data, and disease‐specific survivals (DSS) between 92 patients with oral cavity BSCC and 15,181 patients with SCC. Results High‐grade tumors and distant metastases were more common in the BSCC group ( P ≤0.001). On multivariable analysis controlling for disease stage, BSCC patients had similar DSS to those with typical SCC ( P = 0.231). Although there was a trend favoring definitive radiotherapy for BSCC, there were no significant differences in treatment approach between BSCC and SCC. The choice of treatment modality (radiation, surgery ± radiation) did not reveal a difference in DSS between the two tumor subtypes. Conclusion Analysis of the largest oral cavity BSCC series to date demonstrates that BSCC of the oral cavity carries a comparable prognosis to conventional‐type oral SCC. Level of Evidence 2b. Laryngoscope , 124:1573–1578, 2014