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Intratympanic dexamethasone injection for refractory tinnitus: Prospective placebo‐controlled study
Author(s) -
Choi Seong Jun,
Lee Jong Bin,
Lim Hye Jin,
In Seung Min,
Kim JongYeup,
Bae Kyung Hee,
Choung YunHoon
Publication year - 2013
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.24126
Subject(s) - tinnitus , medicine , loudness , placebo , audiometry , randomized controlled trial , otorhinolaryngology , saline , refractory (planetary science) , randomization , dexamethasone , audiology , prospective cohort study , anesthesia , hearing loss , surgery , physics , alternative medicine , pathology , astrobiology
Objectives/Hypothesis The purpose of this study is to investigate the effectiveness of intratympanic dexamethasone injections (ITDI) for refractory tinnitus. Study Design A prospective, placebo‐controlled, randomized, double‐blind study. Methods Thirty patients with refractory tinnitus who were diagnosed in the Department of Otolaryngology, Ajou University Hospital, Suwon, Republic of Korea, between 2006 and 2007 were enrolled and then were assigned into two groups of ITDI (15 patients) or saline (15 patients) by permuted block randomization. Intratympanic injections were double‐blind performed four times within 2 weeks. After 4 weeks, we analyzed the improvement and aggravation rates of tinnitus using the following parameters: questionnaires, tinnitus handicap index (THI), loudness matching test, frequency, and duration of tinnitus. Results The effectiveness rates of ITDI for refractory tinnitus reported in the tinnitus questionnaires, in the THI, and in the loudness matching test were all 33.3% in the steroid group, and 26.7%, 40.0%, and 26.7% in the saline group, respectively. However, there were no statistically significant differences in both groups. To analyze the therapeutic effect of ITDI on tinnitus under 6 months of its development, the improvement rates reported in the tinnitus questionnaires, in the THI, and in the loudness matching test were all 28.5% in the steroid group, and 40.0%, 40.0%, and 30.0% in the saline group, respectively. There were also no statistically significant differences in both groups. Conclusions ITDI may not be effective for refractory tinnitus. The indication of ITDI for tinnitus needs to be limited to specific cases. Level of Evidence 1b. Laryngoscope , 123:2817–2822, 2013