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Malignant and benign sinonasal paragangliomas
Author(s) -
Papaspyrou Konstantinos,
Welkoborsky HansJuergen,
Gouveris Haralampos,
Mann Wolf J.
Publication year - 2013
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.23985
Subject(s) - medicine , malignancy , nasal cavity , paranasal sinuses , radiology , metastasis , radiation therapy , retrospective cohort study , surgery , pathology , cancer
Objectives/Hypothesis To report on the clinical course and management of sinonasal paragangliomas (PGLs). Study Design and Methods Retrospective chart review of six patients with PGLs of the nasal cavity and paranasal sinuses. Results Three patients had tumors with malignant clinical behavior with cerebral metastases or infiltration of brain and local recurrence, despite surgery and/or radiotherapy, while three patients demonstrated a benign course. Conclusion Sinonasal paragangliomas are frequently malignant. If malignant, they are very aggressive, with rapid local spread as well as high metastatic potential despite surgical resection; and they have a poor prognosis. Malignancy cannot be diagnosed on histology, but only on the basis of clinical behavior. Intracranial metastasis is commonly expected. Long‐term follow‐up, with particular emphasis put on the intracranial structures, is mandatory as recurrences or metastasis may occur even after a long time interval. Level of Evidence 4. Laryngoscope, 123:1830–1836, 2013