Premium
Prognostic significance of HIF‐1a, CA‐IX, and OPN in T1–T2 laryngeal carcinoma treated with radiotherapy
Author(s) -
Wachters Jan E.,
Schrijvers Michiel L.,
SlagterMenkema Lorian,
Mastik Mirjam,
Bock Geertruida H.,
Langendijk Johannes A.,
Kluin Philip M.,
Schuuring Ed,
Laan Bernard F. A. M.,
Wal Jacqueline E.
Publication year - 2013
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.23831
Subject(s) - medicine , hazard ratio , proportional hazards model , radiation therapy , confidence interval , oncology , clinical significance , carcinoma , survival analysis , cohort , larynx , gastroenterology , retrospective cohort study , immunohistochemistry , pathology , surgery
Objectives/Hypothesis To examine the prognostic value of hypoxia inducible factor HIF‐1a, CA‐IX, and OPN on clinical outcome in patients with T1–T2 supraglottic laryngeal squamous cell carcinoma (LSCC) treated with primarily radiotherapy (RT). Study Design Retrospective cohort study. Methods Tumor tissue sections of 60 patients with T1–T2 supraglottic LSCC treated with primarily radiotherapy were assessed immunohistochemically for expression of HIF‐1a, CA‐IX, and OPN. The relationship of protein expression and classical clinical parameters with clinical outcome was studied, using Cox regression and Kaplan‐Meier survival analyses. Results Neither HIF‐1a nor CA‐IX was of prognostic significance toward local control or overall survival in T1–T2 supraglottic LSCC. Cox regression survival analysis showed no relation between HIF‐1a or CA‐IX expression and local control (HR [hazard ratio] 1.07, CI [95% confidence interval] 0.29–3.87; HR 0.34, CI 0.04–2.58). Furthermore, OPN expression was not associated with local control (HR 1.37, CI 0.45–4.17) and overall survival (HR 0.99, CI 0.44–2.21). Our earlier findings in T1–T2 glottic LSCC (Schrijvers et al., 2008) could not be confirmed. Conclusion The absence of prognostic significance for HIF‐1a and CA‐IX toward local control in supraglottic LSCC, unlike glottic LSCC, suggests that supraglottic LSCC might represent another biological entity. Level of Evidence N/A. Laryngoscope , 123:2154–2160, 2013