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The utility of the potassium titanyl phosphate laser in modulating vocal fold scar in a rat model
Author(s) -
Sheu Mike,
Sridharan Shuam,
Paul Benjamin,
Mallur Pavan,
Gandonu Sonate,
Bing Renjie,
Zhou Hang,
Branski Ryan C.,
Amin Milan R.
Publication year - 2013
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.23745
Subject(s) - potassium titanyl phosphate , fibrosis , medicine , extracellular matrix , context (archaeology) , matrix metalloproteinase , vocal folds , pathology , gene expression , wound healing , surgery , gene , laser , larynx , biology , microbiology and biotechnology , paleontology , biochemistry , physics , optics
Objectives/Hypothesis We hypothesize that the KTP laser has the potential to augment wound healing in a rat model, and this modality may serve as a therapeutic tool for the management of vocal fold fibrosis. Study Design Prospective, laboratory animal study. Methods Rats were subjected to either vocal fold injury ± KTP laser treatment at low energy to simulate clinically relevant endpoints. In addition, cohorts were subjected to therapeutic KTP laser alone. Endpoints included the analyses of gene expression data related to the acute inflammatory response and extracellular matrix deposition and organization. Results Therapeutic KTP treatment was associated with an additive effect on inflammatory gene expression in the context of the injured rat vocal fold mucosa. A similar additive effect was observed for matrix metalloproteinase gene expression, similar to data previously reported in the dermatology literature. However, histologically, the KTP had little effect on established vocal fold fibrosis. Conclusions These data are the first to attempt to provide mechanistic insight into the clinical utility of angiolytic lasers for vocal fold scar. Similar to previous data obtained in the skin, it appears that these effects are mediated by MMPs. Level of Evidence NA. Laryngoscope , 123:2189–2194, 2013