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Fulminant epstein‐barr virus‐associated hemophagocytic lymphohistiocytosis
Author(s) -
Bohne Silvia,
Kentouche Karim,
Petersen Iver,
Fritzenwanger Michael,
Pletz Mathias W.,
Lehmberg Kai,
La Rosée Paul,
GuntinasLichius Orlando
Publication year - 2013
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.23433
Subject(s) - hemophagocytic lymphohistiocytosis , fulminant , epstein–barr virus , virology , medicine , virus , immunology , pathology , disease
Hemophagocytic lymphohistiocytosis (HLH) is a rare, severe, and often fatal disorder. Its hereditary and sporadic form can present as a significant diagnostic challenge to the otolaryngologist. This report describes two fatal cases of adult patients with HLH initially presented as infectious mononucleosis to an otorhinolaryngologist. The clinical presentation, serological and histological features, and management are discussed.