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Accuracy of the current TNM classification in predicting survival in patients with sinonasal mucosal melanoma
Author(s) -
Koivunen Petri,
Bäck Leif,
Pukkila Matti,
Laranne Jussi,
Kinnunen Ilpo,
Grénman Reidar,
Mäkitie Antti A.
Publication year - 2012
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.23343
Subject(s) - medicine , mucosal melanoma , melanoma , stage (stratigraphy) , retrospective cohort study , log rank test , cancer staging , survival analysis , cancer , oncology , paleontology , cancer research , biology
Objectives/Hypothesis: The first International Union Against Cancer (UICC) TNM classification for aerodigestive malignant mucosal melanoma was not published until 2009, and since then, only a few studies have evaluated the accuracy of this staging system. Our aim was to evaluate the accuracy of this UICC staging system for sinonasal malignant mucosal melanoma (SMMM) in a nationwide survey. Study Design: Retrospective, population‐based, multicenter study. Methods: The hospital surgical and discharge registries were used to identify the patients. A database including demographic and clinicopathologic variable was created. Results: Altogether, 50 SMMM patients diagnosed in Finland from 1990 to 2004 were evaluated. Three‐ and 5‐year overall survival rates were 44% and 27%, respectively. Significant differences in overall survival according to T classification ( P = .028, log rank) and stage ( P = .02, log rank) were found. Tumor extension to the sphenoid sinus had a significant negative impact on survival (n = 11, P = .03, log rank). Conclusions: The current UICC staging system for mucosal melanoma provides a useful format for staging SMMMs in clinical settings. Laryngoscope, 2012