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Common genetic variants in the 8q24 region and risk of papillary thyroid cancer
Author(s) -
Neta Gila,
Yu ChuLing,
Brenner Alina,
Gu Fangyi,
Hutchinson Amy,
Pfeiffer Ruth,
Sturgis Erich M.,
Xu Li,
Linet Martha S.,
Alexander Bruce H.,
Chanock Stephen,
Sigurdson Alice J.
Publication year - 2012
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.23209
Subject(s) - single nucleotide polymorphism , papillary thyroid cancer , snp , biology , odds ratio , chromosomal region , case control study , logistic regression , genetics , genotype , thyroid cancer , genetic association , multiple comparisons problem , false discovery rate , oncology , medicine , cancer , gene , chromosome , statistics , mathematics
Abstract Objectives/Hypothesis: Single nucleotide polymorphisms (SNPs) in the 8q24 chromosomal region identified from genome‐wide scans have been associated with the risk of several cancers, including breast (rs1562430), prostate (rs1447295), and colon (rs6983267). A genome‐wide scan in 26 families with papillary thyroid cancer (PTC) also found susceptibility loci in 8q24, supporting a closer evaluation of this chromosomal region in relation to the risk of sporadic PTC. Study Design: Case‐control study. Methods: We evaluated 157 tag SNPs in the 8q24 chromosomal region between 120.91 Mb and 128.78 Mb (including rs1562430, rs1447295, and rs6983267) in a case‐control study of 344 PTC cases and 452 age and gender frequency‐matched controls. We used logistic regression to estimate odds ratios and compute P values of linear trend for PTC with genotypes of interest. To account for multiple comparisons, we applied the false discovery rate (FDR) method. Results: We did not find a significant association between rs1562430, rs1447295, or rs6983267 and PTC risk. We found that one SNP (rs4733616) was associated with PTC risk at P = .003, and 12 other SNPs were associated with PTC risk at P < .05. However, no SNPs remained significant after FDR correction. Conclusions: Our findings do not support a strong association between SNPs in the 8q24 chromosomal region and risk of sporadic PTC, but several SNPs with small effects might exist.