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Early changes in apparent diffusion coefficients predict radiosensitivity of human nasopharyngeal carcinoma xenografts
Author(s) -
Pan Jianji,
Zang Lele,
Zhang Yu,
Hong Jinsheng,
Yao Yiqi,
Zou Changyan,
Zhang Lurong,
Chen Yunbin
Publication year - 2012
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.23208
Subject(s) - nasopharyngeal carcinoma , effective diffusion coefficient , nuclear medicine , radiosensitivity , medicine , significant difference , pathology , radiation therapy , magnetic resonance imaging , radiology
Objectives/Hypothesis: Our objective was to predict the radiosensitivity of human nasopharyngeal carcinoma xenografts in nude mice models through an examination of early changes in apparent diffusion coefficient (ADC) values. Study Design: Randomized. Methods: BALB/c‐nu nude mice (n = 20) were divided into two groups that were subcutaneously injected with CNE1 or CNE2 cell lines. Xenograft volumes were measured after tumor formation, mice were scanned with a diffusion‐weighted imaging sequence, and the mean ADC values were measured (ADC 0 ). Fifteen to 20 hours after tumors received 15 Gy, mice were scanned again and ADC values (ADC 1 ) were measured. Results: ADC 0 and ADC 1 values of the CNE1 group showed no significant difference ( P = .692). The difference between the ADC 0 and ADC 1 values of the CNE2 group was statistically significant ( P < .001). ADC 0 values of the two groups exhibited no statistically significant difference ( P = .204). ADC 1 , ADC 1‐0 , and ΔADC of the two groups exhibited statistically significant differences ( P < .001; P = .001 and .002, respectively). After irradiation, volume changes ΔV 8 , ΔV 10 , and ΔV 12 of two groups were statistically different (all P < .001). Pearson correlation analysis showed ADC 1‐0 and ΔADC were positively correlated with ΔV 8 , ΔV 10 , and ΔV 12 . The cut point was found by means of a receiver operating characteristic curve, and the ΔV 12 of the two redivided groups showed a statistically significant difference ( P = .001). Conclusions: This study found that changes in ADC values correlated with volume changes after irradiation. Therefore, ADC values have the potential to predict the radiosensitivity of nasopharyngeal carcinoma xenografts. Laryngoscope, 2012