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Prospective testing of mucoepidermoid carcinoma for the MAML2 translocation: Clinical Implications
Author(s) -
Chiosea Simion I.,
Dacic Sanja,
Nikiforova Mari.,
Seethala Raja R.
Publication year - 2012
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.22419
Subject(s) - chromosomal translocation , prospective cohort study , fluorescence in situ hybridization , mucoepidermoid carcinoma , stage (stratigraphy) , medicine , carcinoma , cohort , pathology , oncology , gastroenterology , biology , genetics , gene , paleontology , chromosome
Objectives/Hypothesis: Mucoepidermoid carcinoma (MEC) with MAML2 translocation is believed to be associated with lower clinical stage, lower histologic grade, and better outcome. We summarized our prospective experience testing MEC for the MAML2 translocation. Study Design: Prospective cohort study. Methods: One hundred eighteen head and neck tumors (55 MECs and 63 mimics) were prospectively tested for MAML2 translocation by fluorescence in situ hybridization as part of clinical care during a 36‐month period. Results: MAML2 translocation was identified in 41 of 55 (75%) cases diagnosed as MEC. Translocation status did not correlate significantly with histologic grade, age, gender, tumor site, or T stage. Conclusions: Routine testing for MAML2 translocation by fluorescence in situ hybridization is feasible and useful in confirming the diagnosis of MEC. The lack of significant correlation with histologic grade or pathologic stage implies that the previously reported prognostic value of the MAML2 translocation may be an artifact of misclassification of MEC as other tumors.