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Examination of Bone Ossification Markers in Cochlear Development
Author(s) -
Chang Jolie,
Butcher Kristin,
Akil Omar,
Schneider Rich,
Lustig Lawrence,
Alliston Tamara
Publication year - 2011
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.22269
Subject(s) - medicine , orthopedic surgery , otorhinolaryngology , butcher , general surgery , surgery , archaeology , history
The otic capsule is unique from other bone in the body. It has limited bone turnover and remodeling and has been described as the “hardest” bone in the body (Chang 2010). Several developmental bone defects are associated with hearing loss including osteogenesis imperfecta, fibrous dysplasia, craniofacial dysplasias and craniosynostoses. Elucidating otic capsule development will lead to a better understanding of the pathogenesis of these developmental bone diseases and how they affect hearing function. The goal of these studies is to examine the spatial and temporal expression pattern of developmental ossification marker genes in the otic capsule.