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Assessing the Prevalence and Implications of Fungal Colonization in Chondroradionecrosis of the Larynx
Author(s) -
Fichandler Craig E.,
Farghaly Hannan I.,
Bumpous Jeffrey M.
Publication year - 2011
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.22233
Subject(s) - medicine , gerontology , library science , computer science
evidence of Candidiasis on H&E staining. • Of note, the two patients who exhibited candidiasis on H&E staining had concomitant Hepatitis C infections. • Eighteen percent (9/50) of the persistent tumors had a pathologic report that mentioned evidence of chondroradionecrosis (necrosis, ulceration), with an additional 22% (11/50) showing “post radiation changes” (fibrosis, hyalinization). • None of these pathology reports for persistent tumor mentioned fungal colonization nor invasion on H&E stains. • Of the thirty one previously irradiated larynges with persistent disease, twenty (64.5%) were positive for fungal invasion seen after special staining. • In comparison, none of the primary surgical specimens evidenced invasion, and only two showed non-invasive fungal elements. • A two-tailed unpaired t-test showed no statistical difference between the chondroradionecrosis and persistent disease group regarding time until resection after radiation, t(53) = 0.12, p=0.9. Assessing the Prevalence and Implications of Fungal Colonization in Chondroradionecrosis of the Larynx Craig E. Fichandler, M.D.1,3, Hannan I. Farghaly, M.D.2, Jeffrey M. Bumpous, M.D.1,3 Division of Otolaryngology1, Department of Pathology2, Brown Cancer Center3 University of Louisville School of Medicine