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Proinflammatory Mediators Upregulate IMP‐3 in HNSCC
Author(s) -
Anastasiou Christine,
Luo Jie,
Lin Yuan,
Dennis Miranda,
Elashof David,
Abemayor Elliot,
St John Maie
Publication year - 2011
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.22218
Subject(s) - computer science
Figure 7. Knocking down NFkB leads to diminished IMP-3 expression. HNSCCs are notably aggressive cancers which cause death primarily due to metastases2. Metastasis involves a complex change in epithelial cell behavior wherein the cell locally invades through the epithelial basement membrane, enters blood or lymph vessels, travels through the circulation, exits the vessel, and replicates at a distant organ. Growing evidence suggests such enhanced mobility requires the cell undergo an epithelial-mesenchymal transition. EMT is a normal part of embryonic development. Therefore, it has been hypothesized that in adults the reactivation of genes involved in embryonic EMT underlies the mechanism of cancer metastasis3.