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Histological assessment of cervical lymph nodes provides prognostic information for Head and Neck Squamous Cell Carcinoma (HNSCC) and identifies high risk patients most likely to benefit from surgery plus chemoradiotherapy (CRT)
Author(s) -
Wan Xiao,
Egloff Ann Marie,
Johnson Jonas
Publication year - 2011
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.22045
Subject(s) - head and neck squamous cell carcinoma , medicine , chemoradiotherapy , oncology , cancer , overall survival , head and neck cancer
Methods: HNSCC surgical patients who had tumor resection and neck dissection at our institution from 1980 through 2007 were included in this retrospective study (n=1534). Cases were categorized according to number of positive cervical nodes (no positive nodes (n=719), 1-2 positive nodes (n=459) or 3+ positive nodes (n=351)) and by ECS status as negative (n=1048) or positive (n=415). Differences in disease-free survival (DFS) and overall survival (OS) were assessed using KaplanMeier and log-rank tests.