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Clinical features, health‐related quality of life, and adult voice in juvenile‐onset recurrent respiratory papillomatosis
Author(s) -
Ilmarinen Taru,
Nissilä Heljä,
Rihkanen Heikki,
Roine Risto P,
PietarinenRuntti Petra,
Pitkäranta Anne,
Aaltonen LeenaMaija
Publication year - 2011
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.21332
Subject(s) - recurrent respiratory papillomatosis , juvenile , quality of life (healthcare) , medicine , respiratory system , audiology , larynx , biology , surgery , genetics , nursing
Objectives/Hypothesis: To determine clinical features, health‐related quality of life, and adult voice in patients with a history of juvenile‐onset recurrent respiratory papillomatosis (JORRP). Study Design: Case‐control study. Methods: All 32 patients with JORRP treated at Helsinki University Hospital between 1975 and 1994 were invited to an outpatient visit in spring 2008, and 18 of them (56%) entered the study. Each patient had an age‐ and gender‐matched control subject with similar smoking habits. Videolaryngostroboscopy was performed and voice quality determined by acoustic and perceptual analysis. Voice‐quality characteristics of the whole patient group and the recurrence‐free patients were examined separately. Subjective voice‐related disability was studied with voice handicap index (VHI) and health‐related quality of life with a 15D questionnaire. Results: Acoustic analysis showed that patients had statistically significantly higher values in percent jitter, percent shimmer, and noise‐to‐harmonics ratio. Perceptual analysis indicated higher scores for patients in overall grade, roughness, breathiness, and strain. Acoustic and perceptual values for recurrence‐free patients (n = 14) were also significantly higher than those for their matched paired controls. No statistically significant differences emerged for handicap related to voice or to health‐related quality of life. Four study patients (22%) had undergone tracheotomy, indicating severity of juvenile‐onset disease. Conclusions: JORRP is a risk factor for permanent laryngeal pathology and voice‐disturbances in adulthood. Laryngoscope, 2011