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Alcohol Induces Reactive Oxygen Species and Migration in Keratinocytes
Author(s) -
Helkin Alex W.,
Nguyen HoangLan T.,
Samara Ghassan J.
Publication year - 2010
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.21216
Subject(s) - samara , library science , citation , computer science , biology , ecology
CONTACT Alex Helkin SUNY at Stony Brook Email: alex.helkin@stonybrook.edu Phone: 631.455.6942 Ethanol is synergistic with tobacco in HNSCC carcinogenesis. While ethanol or tobacco, alone, increases the risk of HNSCC 2to 6-fold, this risk increases to 50-fold with both ethanol and tobacco. Reactive oxygen species (ROS) has been implicated in numerous cellular processes associated with malignancy, including enhancement of cell proliferation, DNA damage, and cell migration.