Premium
AM‐111 prevents hearing loss from semicircular canal injury in otitis media
Author(s) -
Grindal Tyler C.,
Sampson Edith M.,
Antonelli Patrick J.
Publication year - 2010
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.20759
Subject(s) - medicine , round window , hearing loss , semicircular canal , audiology , middle ear , auditory brainstem response , inner ear , ear canal , surgery , cochlea , anatomy , vestibular system , radiology
Objectives/Hypothesis: Iatrogenic semicircular canal (SC) transection during mastoidectomy for chronic otitis media often leads to profound hearing loss. AM‐111, an apoptosis inhibitor, has been shown to mitigate hearing loss resulting from a variety of inner ear injuries. The goal of this study was to determine if round window application of AM‐111 following SC transection in the presence of Pseudomonas aeruginosa otitis media (PA‐OM) may reduce the associated hearing loss. Study Design: Prospective, randomized, controlled study in an animal model. Methods: PA‐OM was induced bilaterally in 34 guinea pigs. After 3 days, both bullae were opened and the lateral SC of one ear was transected. AM‐111 or vehicle was applied topically to the round window of the ear that had undergone SC transection. Hearing was assessed with auditory brainstem responses. Results: The mean change in hearing thresholds was significantly less in transected ears treated with AM‐111 than those receiving vehicle alone when testing with clicks (22.1 dB vs. 35.0 dB; P = .019) and at 4kHz (11.3 dB vs. 40.0 dB; P = .021). A similar trend was shown with 16 kHz tone pips (27.7 dB vs. 41.1 dB; P = .119). Conclusions: AM‐111 prevents hearing loss from SC transection in the guinea pig model of PA‐OM. Laryngoscope, 2010