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Diabetes‐related changes in auditory brainstem responses
Author(s) -
KonradMartin Dawn,
Austin Donald F.,
Griest Susan,
McMillan Garnett P.,
McDermott Daniel,
Fausti Stephen
Publication year - 2010
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.20636
Subject(s) - medicine , audiology , diabetes mellitus , auditory brainstem response , covariate , hearing loss , cardiology , endocrinology , mathematics , statistics
Objectives/Hypothesis: Determine effects on auditory brainstem response (ABR) of diabetes mellitus (DM) severity. Study Design: A cross‐sectional study investigating DM severity and ABR in military Veteran subjects with (166) and without (138) DM and with no more than moderate hearing loss. Methods: Subjects were classified by three age tertiles (<50, 50–56, and 57+). DM severity was classified as insulin‐dependent (IDDM), non–insulin‐dependent (NIDDM), or no DM. Other DM measures included serum glucose, HbA1c, and several DM‐related complications. ABR measures included wave I, III, and V latencies; I–III, III–V, and I–V latency intervals; and wave V amplitude; for each ear at three repetition rates (11, 51, and 71 clicks/second), and both polarities. Outcomes were stratified by age tertile and adjusted for pure tone threshold at 3 kHz. Repeated measures multivariate analysis of covariance modeled the ABR response at each repetition rate for DM severity (main effect) and hearing at 3 kHz (covariate). Modeled contrasts between ABR variables in subjects with and without DM were examined. Results: Significant differences existed between no DM and IDDM groups in the younger tertile only. Adjusting for threshold at 3 kHz had minimal effect. Self‐reported noise exposure was not related to ABR differences, but HbA1c and poor circulation were. Conclusions: IDDM is associated with an increased wave V latency, wave I–V interval, and reduced wave V amplitude among Veterans under 50 years. Results were related to several DM complications. Laryngoscope, 2010