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The Effect of Cidofovir Injection Concurrent with Surgical Resection for Adult Onset Recurrent Respiratory Papillomatosis
Author(s) -
Eisenbeis John F.,
Sappington Joshua M.
Publication year - 2009
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.20388
Subject(s) - cidofovir , recurrent respiratory papillomatosis , citation , medicine , resection , presentation (obstetrics) , surgical resection , history , library science , surgery , computer science , virology , larynx , virus
Recurrent Respiratory Papillomatosis (RRP) is a rare disease characterized by benign exophytic growths that have a tropism for the larynx, but may also spread distally into the lungs. The papillomas are caused by the Human Papilloma Virus (HPV) most often types 6 or 11. This disease demonstrates a bimodal distribution with onset during pediatric years or during adult years. The mainstay treatment for this condition is surgical resection of growths. Difficulty arises in treating patients with this disease because of its propensity to recur after surgical resection and the possibility of distal spread. This has led to the search for effective adjuvant therapies. Cidofovir, an antiviral agent, is currently being used off-label as adjuvant therapy in RRP. Previous studies have demonstrated efficacy for this off-label use, specifically intralesional injections.4 This study examined treating Adult-Onset RRP (AORRP) patients with cidofovir injections at the time of surgical resection. The lesions themselves were not injected but the surgical bed was injected following microdebrider resection. This standard of care differs from intralesional injection techniques previously described in the literature.