Premium
Prognostic Indicators and Survival in Oral Cavity and Oropharyngeal Cancer
Author(s) -
Champagne Jason P.,
Weinberger Paul M.,
Jackson Lana L.
Publication year - 2009
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.20331
Subject(s) - citation , presentation (obstetrics) , library science , section (typography) , oral cavity , computer science , medicine , dentistry , operating system , radiology
References Materials and Methods Patient population consisted of 55 men (77.5%) and 16 women (22.5%) with a mean age of 58.7 years. Perineural invasion, extracapsular spread and stage at presentation were not significantly associated with overall survival or time to recurrence. In contrast, overall survival and median time to recurrence were significantly decreased (P < 0.05) in individuals whose pathology demonstrated lymphovascular invasion, regardless of tumor stage (P < 0.0001). In the United States, cancer of the oral cavity and oropharynx is diagnosed in 35,000 individuals and is responsible for approximately 7500 deaths annually.1 Several histopathologic findings are associated with head and neck squamous cell carcinoma (SCCA) including those found in the oral cavity and oropharynx, however few studies investigating a relationship between these findings and overall survival outcomes exist. Knowledge of indicators of poorer outcomes may help stratify treatment methods and lead to improvements in patient survival. We, therefore, intend to identify indicators that influence recurrence and overall survival in oral cavity and oropharyngeal SCCA.