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Paraneoplastic Anti‐Hu Neuronopathy Secondary to a Myxoid Chondrosarcoma in the Head and Neck Region
Author(s) -
Ow Thomas J.,
Jacobson Adam S.,
Boniece Irene R.,
Wenig Bruce M.,
Khorsandi Azita S.,
Urken Mark L.
Publication year - 2009
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.20314
Subject(s) - head and neck , presentation (obstetrics) , citation , medicine , art history , art , library science , computer science , surgery
Case Report A 40 year-old gentleman presented to the otolaryngology office for evaluation of a left supraclavicular mass. Upon review of his history, it was found that the patient had noticed numbness of his arms, legs and trunk, which had developed 23 weeks previously. On physical examination the patient had no reflexes, tonic pupils, and orthostatic hypotension. Workup revealed that the patient had a sensorimotor polyneuropathy. He tested positive for serum anti-Hu antibodies. The patient underwent a left neck dissection including resection of the supraclavicular mass, and he was found to have a myxoid chondrosarcoma with metastases to several cervical lymph nodes. The tumor stained diffusely with anti-Hu antibodies. Since surgery, the patient has received intravenous immunoglobulin and Tacrolimus with slow progression of his neurologic disturbance.