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IgE‐mediated fungal allergy in allergic fungal sinusitis
Author(s) -
Pant Harshita,
Schembri Mark A.,
Wormald Peter J.,
Macardle Peter J.
Publication year - 2009
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.20170
Subject(s) - fungal sinusitis , allergy , immunoglobulin e , immunology , sinusitis , respiratory hypersensitivity , medicine , microbiology and biotechnology , biology , antibody
Abstract This review will address the current knowledge of the pathogenic mechanisms in allergic fungal sinusitis (AFS) and the basis for the current classification of a subgroup of chronic rhinosinusitis patients. Special attention is directed to the role of immunoglobulin E (IgE)‐mediated fungal allergy in the pathogenesis of AFS. Concepts relating to the mucosal inflammatory response are introduced, as a knowledge of the reactions of the sinus mucosal cells can lead to a better understanding of the mechanisms perpetuating and maintaining the chronic inflammation. Laryngoscope, 2009