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Vocal fold augmentation with calcium hydroxylapatite: Twelve‐month report
Author(s) -
Rosen Clark A.,
GartnerSchmidt Jackie,
Casiano Roy,
Anderson Timothy D.,
Johnson Felicia,
Remacle Marc,
Sataloff Robert T.,
Abitbol Jean,
Shaw Gary,
Archer Sanford,
Zraick Richard I.
Publication year - 2009
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.20126
Subject(s) - phonation , medicine , vocal fold paralysis , visual analogue scale , vocal folds , audiology , prospective cohort study , surgery , paralysis , larynx
Objectives: To evaluate the long‐term effectiveness of calcium hydroxylapatite (CaHA) vocal fold injection for patients with glottal insufficiency. Study Design: Multicenter, open‐label, prospective clinical study of CaHA vocal fold injection. Methods: Each patient served as his/her own control. Voice‐related outcome measures were collected for pre‐injection, 1, 3, 6, and 12 months. Results: Sixty‐three patients were available for evaluation. Fifty‐three percent of the injection procedures were done in the office. Fifty‐seven percent of patients were diagnosed with unilateral paralysis and 43% with glottal incompetence with mobile vocal folds. Patient satisfaction 12 months after injection showed 67% reporting a significant improvement in voice and 81% reporting at least a moderate improvement in voice. Utilizing the Voice Handicap Index–10, visual analog scale (vocal effort), Consensus Assessment Perceptual Evaluation V (judgments of voice severity), and objective voice measures of glottal closure (maximum phonation time and S:Z ratio), paired t tests showed significant improvements after treatment. A 22% further treatment rate was found at the 12‐month time point. Conclusions: One‐year results in this large cohort of patients with glottal incompetence treated with CaHA vocal fold injection demonstrate that excellent clinical results were achieved. Laryngoscope, 2009