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Bisphosphonate‐related osteonecrosis of the skull base
Author(s) -
Khan Aayesha M.,
Sindwani Raj
Publication year - 2009
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.20094
Subject(s) - medicine , skull , bisphosphonate , maxilla , otorhinolaryngology , sinusitis , osteonecrosis of the jaw , brain abscess , paranasal sinuses , dentistry , surgery , abscess , osteoporosis
Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity. Most cases are managed by oral surgeons with only a handful of reports appearing in the otolaryngology literature. We present a unique case of extensive BRONJ involving the maxilla, sinuses, and skull base, complicated by sinusitis and an intracranial abscess. This is the first description of BRONJ involving the skull base. The pathogenesis and management of this process are reviewed. Laryngoscope, 119:449–452, 2009