Premium
The Percentage of Cells in DNA Synthesis in Epidermoid Carcinomas of the Head and Neck: A Preliminary Report
Author(s) -
Cinberg James Z.,
Chang Tsueng H.,
Bases Robert,
Molnar John
Publication year - 1980
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.1980.90.6.920
Subject(s) - larynx , in vivo , lymph node , epidermoid carcinoma , pharynx , radiation therapy , head and neck , pathology , stage (stratigraphy) , antibody , medicine , chemotherapy , lymph , metastasis , nuclear medicine , basal cell , biology , surgery , cancer , immunology , paleontology , microbiology and biotechnology
The in vivo study of cell kinetics of squamous carcinomas of the head and neck is in its infancy. One cell kinetic parameter, the labelling index (LI), the percentage of cells actively replicating DNA, was estimated in carcinomas of the oral cavity (10), larynx (6) and pharynx (5) by an histochemical immunoglobulin technique developed recently in our laboratory: the antinucleoside antibody technique (ANIP‐LI). Data from earlier experiments using autoradiography (3H‐thymidine) have established that the enzyme‐antibody and isotopic techniques are equivalent. The LI ranged from 1 to 30 with a mean of 13 in this group of tumors. The LI could not be evaluated for 14% (3/21) of the specimens. The 3 patients with tumors not suitable for ANIP‐LI had received a full course of radiotherapy and/or chemotherapy before they had entered our study. The higher the LI of the tumor, the greater the liklihood that the surgical stage would be higher than the clinical stage, most often as a result of clinically unrecognized lymph node metastasis. However, the number of tumors sampled was inadequate for a statistical trend to be identified. The potential for the LI to be useful in the formulation of improved therapeutic strategies awaits the accumulation of more data from studies currently in progress.