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Progressive Necrotizing External Otitis: Treatment with Ticarcillin and Tobramycin
Author(s) -
Horwitz Melton J.,
Templeton Terry P.
Publication year - 1977
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.1977.87.11.1836
Subject(s) - carbenicillin , medicine , ticarcillin , tobramycin , otitis , gentamicin , pseudomonas aeruginosa , surgery , antibiotics , piperacillin , microbiology and biotechnology , bacteria , biology , genetics
The history of necrotizing external otitis, its diagnosis and management are reviewed. A case history is presented of a patient who was diagnosed as having progressive necrotizing external otitis with facial paralysis, In spite of standard medical treatment and aggressive surgical management, the disease process continued with progressive involvement of Cranial nerves IX and X. The Pseudomonas aeruginosa bacteria developed an increased minimal inhibitory concentration (MIC) to carbenicillin and gentamicin by requiring near toxic blood levels to be effective. Investigational ticarcillin (α‐carboxy‐3‐thienylmethylpenicillin) and tobramycin were used successfully in resolving the infection.