Open AccessRetracted: MicroRNA‐129‐5p represses the growth and aggressiveness of oral squamous cell carcinoma via suppressing HMGB1
Author(s) -
Song ChunPing,
Cong JingKe,
Wang MingZhen
Publication year - 2020
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1002/kjm2.12201
Subject(s) - microrna , hmgb1 , gene knockdown , medicine , cancer research , basal cell , phenotype , cell growth , metastasis , cell , cell culture , immunology , pathology , gene , cancer , biology , inflammation , genetics
Recent investigations have suggested that microRNA‐129‐5p (miR‐129‐5p) is commonly dysregulated in multiple types of malignancies. Nevertheless, the roles of miR‐129‐5p in human oral squamous cell carcinoma (OSCC) are not well explored. Herein, we demonstrated that miR‐129‐5p was down‐expressed in OSCC cells and tissues. Moreover, miR‐129‐5p overexpression restrained the growth, migration ability, and invasiveness of OSCC cells. Notably, high‐mobility group box 1 protein ( HMGB1 ) was identified as a downstream target of miR‐129‐5p. Additional, knockdown of HMGB1 suppressed the growth and aggressive phenotypes of human OSCC cells. Importantly, re‐expression of HMGB1 impaired the inhibitory impacts of miR‐129‐5p on the metastasis of OSCC cells. Altogether, these results implied that miR‐129‐5p restrained the aggressiveness of OSCC cells through modulating HMGB1 .