Open AccessStat‐3 signaling promotes cell proliferation and metastasis of gastric cancer through PDCD4 downregulation
Author(s) -
Yang YueLou,
Liu Pei,
Li Dong,
Yang Qun,
Li Bin,
Jiang XiangJun
Publication year - 2020
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1002/kjm2.12159
Subject(s) - downregulation and upregulation , cancer research , medicine , cell growth , cancer , metastasis , cancer cell , stat3 , signal transduction , regulator , cell , microbiology and biotechnology , biology , gene , biochemistry , genetics
The present study explored a new downstream regulator of Stat‐3 signaling, miR‐499‐5p and its target gene programmed cell death 4 (PDCD4) in cell survival and metastasis of gastric cancer. Our results showed that miR‐499‐5p is significantly upregulated in human gastric cancer cell line SGC‐7901. We further demonstrated that miR‐499‐5p promotes gastric cancer cell proliferation and invasion in vitro. Mechanistically, we demonstrated that upregulation of miR‐499‐5p expression associated with inhibition of PDCD4; STAT3 transcriptional activation by IL‐6 is crucial for the upregulation of miR‐499‐5p expression. These results indicate that the STAT3‐miR‐499‐5p‐PDCD4 signaling axis plays an important role in gastric cancer progression and a potentially therapeutic target for gastric cancer treatment.