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Reactions of cobalt(III) complexes with free radicals derived from thymine
Author(s) -
Chakrabarti S.,
Mandal P. C.,
Bhattacharyya S. N.
Publication year - 1994
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.550260703
Subject(s) - chemistry , thymine , radiolysis , radical , photochemistry , adduct , cobalt , electron transfer , radiation chemistry , medicinal chemistry , chemical reaction , inorganic chemistry , organic chemistry , dna , biochemistry
The nature of interaction of Co(III) complexes such as Co(III)EDTA and Co(III)NTA with transient adducts of thymine such as TOH ˙ , T ˙− , and TH ˙ formed in the gamma radiolysis of thymine were studied. The study shows that TOH radicals do not undergo electron transfer reaction with Co(III) complexes whence no radiosensitization of thymine by Co(III) complexes was observed. Electron transfer however, takes place from T ˙− and TH ˙ to Co(III) complexes. A plausible mechanism of radiolysis of thymine in presence of Co(III) complexes is discussed. © 1994 John Wiley & Sons, Inc.