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An operational approach to N ‐Cl‐α‐amino acids decomposition
Author(s) -
Armesto X. L.,
Canle M. L.,
Losada M.,
Santaballa J. A.
Publication year - 1993
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.550250502
Subject(s) - chemistry , protonation , molar absorptivity , decomposition , amino acid , mixing (physics) , reaction rate constant , group (periodic table) , medicinal chemistry , computational chemistry , organic chemistry , kinetics , ion , biochemistry , physics , quantum mechanics , optics
It has been usually thought that the rate of N ‐Cl‐α‐amino acids decomposition changes and that their coefficient of molar absorptivity falls when pH < 5, which has been explained on the basis of a hypothetical process of protonation at the N ‐Cl‐amino group. We have proved: (i) the absence of protonation at the N ‐Cl‐amino group, at least when pH > 2−; (ii) the effect of the method of mixing on the reaction rate; (iii) the absolute necessity of a very careful choice of buffers and solvents; and (iv) the need to check the accuracy of the mathematical model to describe the chemical processes. © 1993 John Wiley & Sons, Inc.
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