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Aromatic nucleophilic substitution reactions of 2‐chloro‐quinoxaline with anilines in ethanol
Author(s) -
Patel R. D.
Publication year - 1992
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.550240604
Subject(s) - chemistry , quinoxaline , ethanol , nucleophilic substitution , kinetics , nucleophilic aromatic substitution , nucleophile , medicinal chemistry , substitution reaction , organic chemistry , computational chemistry , catalysis , physics , quantum mechanics
The reactions of 2‐chloroquinoxaline with anilines in ethanol are found to follow second order kinetics, first order in each reactant. The activation parameters determined, from the rate data at five different temperatures are found to be typical of bimolecular aromatic nucleophilic substitutions (SN2Ar). The rate data are also correlated in terms of Hammett as well as Bronsted relationships.