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Reactivity of tert ‐butoxyl radicals towards substituted indole derivatives
Author(s) -
Encinas M. V.,
Lissi E. A.,
Majmud C.,
Olea A. F.
Publication year - 1991
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.550230902
Subject(s) - chemistry , reactivity (psychology) , hydrogen atom abstraction , radical , indole test , hydrogen atom , photochemistry , medicinal chemistry , computational chemistry , stereochemistry , organic chemistry , group (periodic table) , medicine , alternative medicine , pathology
Tert ‐butoxyl radicals react with indole and methyl substituted derivatives by hydrogen abstraction. For those compounds which are unsubstituted at the N‐atom, hydrogen abstraction takes place almost exclusively at the NH bond. The reactivity of these compounds correlates with their donor electron capacity, pointing to significant contribution of charge transfer to the transition state stability. Substitution at the N atom considerably decreases the reactivity.