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A comparative kinetic study of the N‐Nitrosation of sulfanilamide by cyclohexyl nitrite and by nitrous acid
Author(s) -
Shenton A. J.,
Johnson R. M.
Publication year - 1972
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.550040210
Subject(s) - nitrosation , nitrous acid , chemistry , sulfanilamide , nitrite , nitrous oxide , azo coupling , sodium nitrite , kinetics , organic chemistry , medicinal chemistry , inorganic chemistry , nitrate , biochemistry , physics , quantum mechanics
A comparative study of the kinetics of the N‐nitrosation of sulfanilamide by cyclohexyl nitrite and by nitrous acid has been made, using an automated technique. The results indicate that a common nitrosating species is effective in analogous reactions involving cyclohexyl nitrite or nitrous acid. The N‐nitrosation reaction has been followed spectrophotometrically by coupling the diazotized product with 1‐naphthol. Under certain conditions a competitive reaction takes place in which coupling occurs with unreacted sulfanilamide.