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Spectroscopic and Electrochemical Studies of the Interaction of Some Gold(III) Complexes with Biologically Relevant Thiones
Author(s) -
A. Sulaiman Adam A.,
Omer Khalid H.,
Kawde AbdelNasser,
M. Wazeer M. I.,
Altaf Muhammad,
Musa Musa M.,
Ahmad Saeed,
Isab Anvarhusein A.
Publication year - 2018
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.21149
Subject(s) - chemistry , thiourea , reactivity (psychology) , aqueous solution , electrochemistry , ligand (biochemistry) , hydrolysis , medicinal chemistry , associative substitution , cyclic voltammetry , kinetic energy , chloride , reaction mechanism , inorganic chemistry , organic chemistry , catalysis , electrode , medicine , biochemistry , physics , alternative medicine , receptor , pathology , quantum mechanics
The interaction of gold(III) complexes, [Au( cis ‐DACH)Cl 2 ]Cl and [Au( cis ‐DACH) 2 ]Cl 3 complexes (DACH = cis ‐1,2‐diaminocyclohexane), with 13 C, 15 N‐enriched thiourea (Tu) and 1,3‐diazinane‐2‐thione ligands was investigated. The progress of these reactions was monitored by NMR ( 1 H, 13 C, and 15 N) and UV–vis spectroscopy as well as square wave stripping voltammetry. The kinetic studies of the substitution reactions between the above‐mentioned complexes with thiones in aqueous solutions containing 30 mM KCl, which is used to suppress the hydrolysis of the chloride complexes, were conducted. These reactions were followed under pseudo–first‐order conditions as functions of ligand concentration, pH, and temperature. The activation parameters (Δ H # , Δ S # ) were calculated from Eyring plots, and the negative values of Δ S ≠ lend support for an associative mechanism. The kinetic data also indicated a relatively higher reactivity of [Au( cis ‐DACH)Cl 2 ]Cl than that of [Au( cis ‐DACH) 2 ]Cl 3 toward the thiones.