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Study on the Extraction Kinetics of Ketoconazole with Hydroxypropyl‐β‐Cyclodextrin as a Selector
Author(s) -
Xu Weifeng,
Jiang Pan,
Tang Kewen,
Zhang Panliang,
Zeng Lelin,
Xiong Biquan,
Liu Yu
Publication year - 2017
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.21088
Subject(s) - ketoconazole , chemistry , extraction (chemistry) , enantiomer , kinetics , chromatography , cyclodextrin , inclusion compound , reaction rate constant , stereochemistry , antifungal , medicine , physics , dermatology , quantum mechanics
ABSTRACT This paper reports on the kinetics of extraction of ketoconazole enantiomers in a Lewis cell, which accompanies by an inclusion reaction. The mass transfer model of the extraction process is established based on the homogeneous reaction mechanism and two‐film theory. Factors such as stirring speed, phase contact area, and ketoconazole concentration are separately investigated. The obtained data show the inclusion reaction is a fast reaction. The reactions have been found to be first order for ketoconazole enantiomers and second order for hydroxypropyl‐β‐cyclodextrin with forward rate constants of 1.716 × 10 −3 m 6 /(mol 2 ·s) for (−)‐ketoconazole and 2.067 × 10 −3 m 6 /(mol 2 ·s) for (+)‐ketoconazole.