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The Role of an Alkyl–Phenyl Spacer on the Reactivity of Novel Platinum(II) Complexes with Thiourea Nucleophiles
Author(s) -
Asman Wangoli Panyako,
Jaganyi Deogratius
Publication year - 2017
Publication title -
international journal of chemical kinetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.341
H-Index - 68
eISSN - 1097-4601
pISSN - 0538-8066
DOI - 10.1002/kin.21085
Subject(s) - chemistry , thiourea , nucleophile , associative substitution , reactivity (psychology) , platinum , medicinal chemistry , alkyl , substitution reaction , nucleophilic substitution , organic chemistry , catalysis , medicine , alternative medicine , pathology
The presented work, submitted as a paper, deals with the substitution reactions of mononuclear and dinuclear platinum(II) complexes of di‐2‐pyridylaminodiaquaplatinum(II), ( Pt1 ); di‐2‐pyridylaminomethylbenzenediaquaplatinum(II), ( Pt2 ); 1,2‐bis(di‐2‐pyridylaminomethyl)benzenetetraquaplatinum(II), ( Pt3 ); 1,3‐bis(di‐2‐pyridylamino‐methyl)benzenetetraquaplatinum(II), ( Pt4 ); and 1,4‐bis(di‐2‐pyridylaminomethyl)‐benzenetetraquaplatinum(II), ( Pt5 ). These reactions were carried out on aqua complexes by three nucleophiles, viz., thiourea, N , N ′‐dimethylthiourea, and N , N , N ′ N ′‐tetramethylthiourea under pseudo–first‐order conditions as a function of nucleophile concentration and temperature by stopped‐flow and UV–visible spectrophotometric techniques. In addition, some DFT calculation was performed. The activation parameters support an associative substitution mechanism.